Yokota A, Hirai H, Sato R, Adachi H, Sato F, Hayashi Y, Sato A, Kamio N, Miura Y, Nakano M, Tenen DG, Kimura S, Tashiro K, Maekawa T: C/EBPβ is a critical mediator of IFNα-induced exhaustion of chronic myeloid leukemia stem cells. Blood Advances, 3(3):476-488, 2019.
Nanya M, Yurugi K, Kato I, Hiramatsu H, Kawabata H, Kondo T, Iemura T, Hishida R, Shibutani E, Matsui K, Nakagawa Y, Niwa N, Kasai Y, Roig JM, Arai Y, Miura Y, Takaori-Kondo A, Maekawa T and Hirai H: Successful granulocyte apheresis using medium molecular weight hydroxyethyl starch. Int J Hematol, 110(6):729-735, 2019. doi: 10.1007/s12185-019-02755-2.
Ogawa R, Yamamoto T, Hirai H, Hanada K, Kiyasu Y, Nishikawa G, Mizuno R, Inamoto S, Itatani Y, Sakai Y, Kawada K: Loss of SMAD4 promotes colorectal cancer progression by recruiting tumor-associated neutrophils via CXCL1/8-CXCR2 axis. Clinical Cancer Research, 25(9): 2887-2899, 2019.
総説
Hayashi Y, Yokota A, Harada H, Huang G: Hypoxia/pseudohypoxia-mediated Activation of Hypoxia-Inducible factor-1α in Cancer. Cancer Sci, 110(5); 1510-1517, 2019.
平位秀世, 横田明日美, 前川平: CML幹細胞に対するInterferon-αの作用機構, Bio Clinica vol34(6):74-77, 2019.
横田明日美, 平位秀世: Introduce My Article “C/EBPβ is a critical mediator of IFN-α-induced exhaustion of chronic myeloid leukemia stem cells. Blood Advances.” 臨床血液. 60(7), 864, 2019.
招待講演
Hirai H: C/EBPβ isoforms regulate hematopoietic stem cells under stress conditions. December 4th Symposium “Gene Regulation in Differentiation and Cancer”. Boston, 2019.
学会発表
Sato A, Yokota A, Hayashi Y, Kamio N, Sagai S, Maekawa T and Hirai H: C/EBPβ Isoforms Regulate Proliferation and Differentiation of Regenerating Hematopoietic Stem/Progenitor Cells. American Society of Hematology, 60th Annual Meeting and Exposition, Orlando, 2019.
Yokota A, Zhang L, Feng J, Feng X, Yan X, Huang G: Myelodysplastic Syndromes-Associated Gene Mutations Lead to Pseudohypoxia Condition and Epigenome Hyper-Methylation in Mouse Genetic Models. American Society of Hematology, 60th Annual Meeting and Exposition (Orlando, Florida) December 7, 2019.
Wang J, Hayashi Y, Yokota A, Xu Z, Zhang Y, Huang R, Yan X, Liu H, Ma L, Azam M, Bridges JP, Cancelas JA, Kalfa TA, An X, Xiao Z, Huang G: Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Haematologica, 103(1); 40-50, 2018.
Nakagawa Y, Ashihara E, Yao H, Yokota A, Toda Y, Miura Y, Nakata S, Hirai H, Maekawa T: Multiple myeloma cells adapted to long-exposure of hypoxia exhibit stem cell characters with TGF-β/Smad pathway activation. Biochem Biophys Res Commun., 496(2):490-496, 2018.
Fujii S, Miura Y, Fujishiro A, Shindo T, Shimazu Y, Hirai H, Tahara H, Takaori-Kondo A, Ichinohe T, Maekawa T: Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T cell Populations. Stem Cells, 36(3): 434-445, 2018.
Hirai H: C/EBPβ critically mediated IFNα-induced exhaustion of chronic myeloid leukemia stem cells. The 9th JSH International symposium, Kyoto, 2018.
Atsushi Sato, Asumi Yokota, Yoshihiro Hayashi, Akihiro Tamura, Yasuo Miura, Taira Maekawa and Hideyo Hirai: C/EBPβ isoforms sequentially regulate proliferation and differentiation of regenerating hematopoietic stem/progenitor cells. Twelfth International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia. 2018 Myeloid Stem Cell Development & Leukemia Conference, Cincinnati, 2018.
Torikoshi Y, Shime N, Yokota A, Kamio N, Sato A, Shoji T, Kashiwagi T, Miura Y, Maekawa T, Hirai H: Impact of Hypothermia on Differentiation and Maturation of Neutrophils. American Society of Hematology, 60th Annual Meeting and Exposition, San Diego, 2018.
Yokota A, Zhang L, Yan X, Feng X, Wen L, Freudiger G, Rife M, Woeste A, Hayashi Y, Huang G: Mll-Partial Tandem Duplication (Mll-PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II. American Society of Hematology, 60th Annual Meeting and Exposition (San Diego, California) December 1, 2018.
Yokota A, Hayashi Y, Wang J, Huang R, Zhang L, Yan X, Huang G: Monocytes/Macrophages are Expanded in both Primary and Secondary Erythrocytosis Mouse Models. The Twelfth International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia (Cincinnati, Ohio) May 9, 2018.
Tamura A, Hirai H, Yokota A, Kamio N, Sato A, Shoji T, Kashiwagi T, Torikoshi Y, Miura Y, Tenen DG, and Maekawa M: C/EBPβ is required for survival of Ly6C- monocytes. Blood, 130(16):1809-1818, 2017.
Yokota A, Hirai H, Shoji T, Maekawa T, and Okuda K: Constitutively active ABL family kinases, TEL/ABL and TEL/ARG, harbor distinct leukemogenic activities in vivo. Leukemia, 31(12):2742-2751, 2017.
Yamamoto T, Kawada K Itatani Y, Inamoto S, Okamura R, Iwamoto M, Miyamoto E, Chen-Yoshikawa TF, Hirai H, Hasegawa S, Date H, Taketo MM, Sakai Y. Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-associated Neutrophils through CCL15-CCR1 Axis. Clin Cancer Res, 23(3):833-844, 2017.
Iwasa M, Miura Y, Fujishiro A, Fujii S, Sugino N, Yoshioka S, Yokota A, Hishita T, Hirai H, Andoh A, Ichinohe T, Maekawa T: Bortezomib interferes with adhesion of B cell precursor acute lymphoblastic leukemia cells through SPARC up-regulation in human bone marrow mesenchymal stromal/stem cells. Int J Hematol. 105(5): 587-597, 2017.
Hirata Y, Yoshizawa A, Egawa H, Ueda D, Okamoto S, Okajima H, Yurugi K, Hishida R, Hirai H, Miyagawa-Hayashino A, Maekawa T, Haga H, Uemoto S: Impact of Antibodies that React with Liver Tissue and Donor-specific anti-HLA Antibodies in Pediatric Idiopathic Posttransplantation Hepatitis. Transplantation. 101(5); 1074-1083, 2017.
Fujita M, Kawabata H, Oka T, Hishizawa M, Kitano T, Kondo T, Yamashita K, Yurugi K, Hirai H, Maekawa T, Takaori-Kondo A: A rare case of adult primary autoimmune neutropenia successfully treated with prednisolone. Internal Medicine, 56(11), 1415-1419, 2017.
Fujishiro A, Miura Y, Iwasa M, Fujii S, Sugino N, Andoh A, Hirai H, Maekawa T, Ichinohe T: Effects of acute exposure to low-dose radiation on the characteristics of human bone marrow mesenchymal stromal/stem cells. Inflammation and Regeneration 37:19, eCollection 2017.
Fujii S, Miura Y, Iwasa M, Yoshioka S, Fujishiro A, Sugino N, Kaneko H, Nakagawa Y, Hirai H, Takaori-Kondo A, Ichinohe T, Maekawa T: Isolation of mesenchymal stromal/stem cells from cryopreserved umbilical cord blood cells. J Clin Exp Hematopathol 57: 1-8, 2017. (doi: 10.3960/jslrt.16019)
Hirai H: Regulation of hematopoietic stem cells by C/EBPβ, a transcription factor required for emergency granulopoiesis. Symposium 6: “New world of innate immunity: Unexpected ontogeny and surprising functions”, The 79th Annual Meeting of the Japanese Society of Hematology, 東京, 2017.
Yokota A, Hirai H, Sato A, Kamio N, Hayashi Y, Miura Y, Kimura S, Maekawa T: IFN-α Upregulates the Expression of C/EBPβ and Induces Myeloid Differentiation and Exhaustion of CD34+ CML Stem Cells. American Society of Hematology, 59th Annual Meeting and Exposition, Atlanta, 2017.
Yokota A, Hayashi Y, Wang J, Huang R, Yan X, Zhang Y, Huang G: Monocytes/Macrophages are involved in erythrocytosis caused by both EPO-dependent and -independent activation of EPOR. The American Society of Hematology 59th Annual Meeting and Exposition, Atlanta, 2017.
Sato A, Hirai H, Yokota A, Tamura A, Shoji T, Kashiwagi T, Kamio N, Torikoshi Y, Miura Y, Maekawa T: mTOR-C/EBPβ-c-Myc Axis Regulates the Behavior of Myeloid-Biased Hematopoietic Stem Cells Under Stress Conditions. American Society of Hematology, 59th Annual Meeting and Exposition, Atlanta, 2017.
Yokota A, Hirai H, Sato A, Hayashi Y, Miura Y, Kimura S, Maekawa T: Exhaustion of CD34+ CML-CP stem cells is induced by IFNα through upregulation of C/EBPβ. The 76th Annual Meeting of Japanese Cancer Association, 横浜, 2017.
Sato A, Hirai H, Yokota A, Tamura A, Shoji T, Kashiwagi T, Kamio N, Torikoshi Y, Miura Y, Maekawa T: C/EBPβ endows hematopoietic stem cells with myeloid-bias in stress conditions. The 79th Annual Meeting of the Japanese Society of Hematology, 東京, 2017.
Yokota A, Hirai H, Sato A, Kamio N, Shoji T, Kashiwagi T, Torikoshi Y, Miura Y, Hayashi Y, Kimura S, Maekawa T: IFNα upregulates C/EBPβ in CD34+ CML stem cells and induces their exhaustion. The 79th Annual Meeting of the Japanese Society of Hematology, 東京, 2017.
Inamoto S, Itatani Y, Yamamoto T, Minamiguchi S, Hirai H, Iwamoto M, Hasegawa S, Taketo MM, Sakai Y and Kawada K: Loss of SMAD4 promotes colorectal cancer progression by accumulation of myeloid-derived suppressor cells through CCL15-CCR1 chemokine axis. Clinical Cancer Res, 22(2): 492-501, 2016. doi: 10.1158/1078-0432.CCR-15-0726.
Sugino N, Miura Y, Yao H, Iwasa M, Fujishiro A, Fujii S, Hirai H, Takaori-Kondo A, Ichinohe T, Maekawa T: Early osteoinductive human bone marrow mesenchymal stromal/stem cells support an enhanced hematopoietic cell expansion with altered chemotaxis- and adhesion-related gene expression profiles. Biochem Biophys Res Commun 469(4): 823-829, 2016.
Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, Iwasa M, Fujishiro A, Shoji T, Kashiwagi T, Miura Y, Nakano M, Tashiro K, Maekawa T: The C/EBPβ Transcription Factor Mediates the Effect of IFNα on CML Stem Cells Through Promoting Their Differentiation and Exhaustion. The 5th JCA-AACR Special Joint Conference, Maihama, 2016.
Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, Iwasa M, Fujishiro A, Shoji T, Kashiwagi T, Kamio N, Torikoshi Y, Miura Y, Nakano M, Tashiro K, Maekawa T: C/EBPβ is a critical regulator of CML stem cell differentiation and exhaustion induced by interferon-α. American Society of Hematology, 58th Annual Meeting and Exposition, San Diego, 2016.
Tamura A, Hirai H, Yokota A, Kamio N, Sato A, Shoji T, Kashiwagi T, Torikoshi Y, Iwasa M, Fujishiro A, Miura Y, Maekawa T: C/EBPβ Is Required for Survival of Ly6C- Monocytes after Commitment to Monocyte Lineage through Upregulation of Csf1r. American Society of Hematology, 58th Annual Meeting and Exposition, San Diego, 2016.
Yoshioka S, Miura Y, Iwasa M, Fujishiro A, Sugino N, Fujii S, Nakagawa Y, Sato A, Yokota A, Hirai H, Ichinohe T, Takaori-Kondo A, Maekawa T: Late Adherent Subpopulation in Umbilical Cord Blood Has the Same Characteristics and Hematopoiesis-Supporting Capacity As Mesenchymal Stromal/Stem Cells. American Society of Hematology, 58th Annual Meeting and Exposition, San Diego, 2016.
Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, Miura Y, Nakano M, Tashiro K, Maekawa T: The C/EBPβ transcription factor promotes exhaustion of CML stem cells in response to interferon-α. The 75th Annual Meeting of Japanese Cancer Association, 横浜, 2016.
Fujii S, Miura Y, Iwasa M, Fujishiro A, Sugino N, Sato A, Yokota A, Hirai H, Takaori-Kondo A, Ichinohe T, Maekawa T: Human bone marrow mesenchymal stromal/stem cells modulate IMiDs-induced differentiation of HSPCs. The 78th Annual Meeting of the Japanese Society of Hematology, 横浜, 2016.
Sato A, Hirai H, Yokota A, Tamura A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Ando A, Maekawa T: Stress-induced translational alteration of C/EBPβ isoforms regulates the behavior of HSPCs. The 78th Annual Meeting of the Japanese Society of Hematology, 横浜, 2016.
Sasaki H, Nishiyama A, Koizumi S, Nakabayashi J, Kaneko N, Yokota A, Hirai H, Tamura T: C/EBPβ mediates the repression of Irf8 expression and dendritic cell development by BCR-ABL. The 78th Annual Meeting of the Japanese Society of Hematology, 横浜, 2016.
Fujishiro A, Miura Y, Iwasa M, Fujii S, Sugino N, Sato A, Yokota A, Hirai H, Ando A, Tohyama K, Ichinohe T, Maekawa T: Vitamin K2 supports hematopoiesis through acting on human bone marrow mesenchymal stromal/stem cells: The 78th Annual Meeting of the Japanese Society of Hematology, 横浜, 2016.
Yokota A, Hirai H, Sato A, Tamura A, Shoji T, Kashiwagi T, Fujishiro A, Iwasa M, Miura Y, Hayashi Y, Maekawa T: The C/EBPβ transcription factor mediates exhaustion of CML stem cells induced by IFNα. The 78th Annual Meeting of the Japanese Society of Hematology, 横浜, 2016.
Yokota A, Hirai H, Shoji T, Maekawa T, Okuda K: ABL family kinase, ARG drives mastocytosis in mice by sensitizing HPCs to IL-3 and SCF. The 78th Annual Meeting of the Japanese Society of Hematology, 横浜, 2016.
藤井紀恵, 三浦康生, 藤城 綾, 岩佐磨佐紀, 杉野典子, 平位秀世, 高折晃史, 一戸辰夫, 前川 平: Human bone marrow mesenchymal stromal/stem cells modulate IMiDs-induced differentiation of HSPCs. ヒト骨髄間葉系幹細胞は免疫調節薬による造血幹前駆細胞の分化に影響を及ぼす. The 75th Annual Meeting of Japanese Cancer Association, 横浜, 2016.
Tamura A, Hirai H, Yokota A, Sato A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y and Maekawa T: Accelerated apoptosis of peripheral blood monocytes in Cebpb-deficient mice. Biochem Biophys Res Commun, 464(2): 654-8, 2015. doi: 10.1016/j.bbrc.2015.07.045.
Ashihara E, Munaka T, Kimura S, Nakagawa S, Nakagawa Y, Kanai M, Hirai H, Abe H, Miida T, Yamato S, Shoji S and Maekawa T: Isopentenyl Pyrophosphate Secreted from Zoledronate-Stimulated Myeloma Cells, Activates the Chemotaxis of γδ T Cells. Biochem Biophys Res Commun, 463(4): 650-5, 2015. doi: 10.1016/j.bbrc.2015.05.118.
Yoshioka S, Miura Y, Iwasa M, Fujishiro A, Yao H, Miura M, Fukuoka M, Nakagawa Y, Yokota A, Hirai H, Ichinohe T, Takaori-Kondo A, and Maekawa T: Isolation of mesenchymal stromal/stem cells from small-volume umbilical cord blood units that do not qualify for the banking system. Int J Hematol. 102(2): 218-29, 2015. doi: 10.1007/s12185-015-1828-7.
Cai Y, Hirata A, Nakayama S, VanderLaan PA, Levantini E, Yamamoto M, Hirai H, Wong KK, Costa DB, Watanabe H, Kobayashi SS: ICCAAT/enhancer binding protein beta is dispensable for normal and tumor development in lung. Plos ONE, 10(3): e0120647, 2015. doi: 10.1371/journal.pone.0120647. eCollection 2015.
総説
Hirai H, Yokota A, Tamura A, Sato A and Maekawa T: Non-steady-state hematopoiesis regulated by the C/EBPβ transcription factor. Cancer Science, 106(7):797-802, 2015. doi: 10.1111/cas.12690.
学会発表
Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Iwasa M, Fujishiro A, Shoji T, Miura Y, Maekawa T: IFNα promotes differentiation of BCR-ABL+ leukemic cells through upregulating C/EBPβ. International Society for Experimental Hematology, 44th Annual Scientific Meeting, Kyoto, 2015.
Yokota A, Hirai H, Shoji T, Maekawa T, Okuda K: A Constitutively-Active ABL Family Kinase, TEL-ARG, Induces Lethal Mastocytosis through Sensitizing Hematopoietic Stem/Progenitor Cells to IL-3. American Society of Hematology, 57th Annual Meeting, Orland, 2015.
Sato A, Hirai H, Yokota A, Tamura A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Maekawa T: C/EBPβ Isoforms Distinctively and Collaboratively Regulate the Behavior of Hematopoietic Stem and Progenitor Cells in Regenerative Conditions. American Society of Hematology, 57th Annual Meeting, Orland, 2015.
Tamura A, Hirai H, Yokota A, Sato A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Maekawa T: Csf1r Is a Downstream Target of C/EBPβ in Ly6C¯ Monocytes. American Society of Hematology, 57th Annual Meeting, Orland, 2015.
Fujishiro A, Miura Y, Iwasa M, Fujii S, Tamura A, Sato A, Yokota A, Sugino N, Hirai H, Ando A, Takaori-Kondo A, Ichinohe T, Maekawa T: Vitamin K2 Supports Hematopoiesis through Acting on Bone Marrow Mesenchymal Stromal/Stem Cells . American Society of Hematology, 57th Annual Meeting, Orland, 2015.
Iwasa M, Miura Y, Fujishiro A, Fujii S, Sugino N, Tamura A, Sato A, Yokota A, Yoshioka S, Kito K, Ando A, Hirai H, Takaori-Kondo A, Ichinohe T, Maekawa T: Bortezomib Attenuates Adhesion of B Cell Precursor Acute Lymphoblastic Leukemia Cells to Bone Marrow Mesenchymal Stromal/Stem Cells Via Regulating SPARC Expression. American Society of Hematology, 57th Annual Meeting, Orland, 2015.
Yokota A, Hirai H, Shoji T, Maekawa T, Okuda K: TEL-ARG and TEL-ABL activate distinct differentiation pathways in response to IL-3. The 77th Annual Meeting of the Japanese Society of Hematology, 金沢, 2015
Sato A, Hirai H, Tamura A, Yokota A, Shoji T, Iwasa M, Fujishiro A, Miura Y, Maekawa T:C/EBPβ facilitates cell cycle entry of HSPCs in response to hematological stresses. The 77th Annual Meeting of the Japanese Society of Hematology, 金沢, 2015.
万木紀美子, 平位秀世, 菱田理恵, 丹羽紀実, 三浦康生, 前川平, 菱澤方勝, 近藤忠一, 高折晃史:骨髄移植患者およびドナーの保有するHLA抗体についての検討. The 77th Annual Meeting of the Japanese Society of Hematology, 金沢, 2015.
Fujishiro A, Miura Y, Iwasa M, Tamura A, Sato A, Yokota A, Hirai H, Ando A, Maekawa T, Ichinohe T: Effects of low-dose irradiation on human bone marrow mesenchymal stromal/stem cells. The 77th Annual Meeting of the Japanese Society of Hematology, 金沢, 2015.
Tamura A, Hirai H, Yokota A, Sato A, Shoji T, Iwasa M, Fujishiro A, Miura Y, Maekawa T: M-CSF receptor is a downstream target of C/EBPβ in Ly6C monocytes development. The 77th Annual Meeting of the Japanese Society of Hematology, 金沢, 2015.
Hirai H, Fujishita T, Kurimoto K, Saitou M, Maekawa T, Taketo MM: CCR1-mediated formation of liver microenvironment for colon cancer metastasis. 日本癌学会シンポジウム/共同利用・共同研究拠点シンポジウム「がん幹細胞・微小環境・分子標的~がん進展制御への挑戦」, 金沢, 2015
Ashihara E, Nakagawa Y, Yao H, Takada T, Yokota A, Miura Y, Takata K, Hirai H, Kitamura Y, Maekawa T: Hypoxia-adapted myeloma cells possess stem cell characters. 日本癌学会シンポジウム/共同利用・共同研究拠点シンポジウム「がん幹細胞・微小環境・分子標的~がん進展制御への挑戦」, 金沢, 2015.
Hirai H, Fujishita T, Kurimoto K, Miyachi H, Kitano S, Inamoto S, Itatani Y, Saitou M, Maekawa T, and Taketo MM: CCR1-mediated Accumulation of Myeloid Cells in the Liver Microenvironment Promoting Mouse Colon Cancer Metastasis. Clin Exp Metastasis, 31(8): 977-89, 2014. doi: 10.1007/s10585-014-9684-z.
Yao H, Miura Y, Yoshioka S, Miura M, Hayashi Y, Tamura A, Iwasa M, Sato A, Hishita T, Higashi Y, Kaneko H, Ashihara E, Ichinohe T, Hirai H, Maekawa T: Parathyroid hormone enhances hematopoietic expansion via upregulation of cadherin-11 in bone marrow mesenchymal stromal cells. Stem Cells. 32(8): 2245-55, 2014. doi: 10.1002/stem.1701.
Yoshioka S, Miura Y, Yao H, Satake S, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaori-Kondo A and Maekawa T: C/EBPβ expressed by bone marrow mesenchymal stromal cells regulates early B-cell lymphopoiesis. Stem Cells, 32(3): 730-40, 2014.
Morishima T, Watanabe K-I, Niwa A, Hirai H, Saida S, Tanaka T, Kato I, Umeda K, Hiramatsu H, Saito MK, Matsubara K, Adachi S, Kobayashi M, Nakahata T, Heike T: Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. Haematologica. 99(1): 19-27, 2014. doi: 10.3324/haematol.2013.083873.
学会発表
Hirai H, Fujishita T, Kurimoto K, Saitou M, Maekawa T and Taketo MM: CCR1-Mediated Formation of Liver Microenvironment for Cancer Metastasis. The 56th ASH Annual Meeting, San Francisco, 2014.
Yokota A, Hirai H, Shoji T, Maekawa T and Okuda K. C-Terminal Domain of ABL Family Kinases, ABL and ARG, Defines Their Distinct Leukemogenic Activities in Vivo. The 56th ASH Annual Meeting, San Francisco, 2014.
Tamura A, Hirai H, Yokota A, Sato A, Yao H, Iwasa M, Fujishiro A, Miura Y and Maekawa T: Essential Roles of C/EBPβ in Survival of Ly6C– monocytes. The 56th ASH Annual Meeting, San Francisco, 2014.
Iwasa M, Miura Y, Fujishiro A, Tamura A, Sato A, Yokota A, Nakagawa Y, Yoshioka S, Hirai H, Andoh A, Ichinohe T and Maekawa T: Effects of Irradiation on the Functional Characteristics of Human Bone Marrow Mesenchymal Stromal/Stem Cells. The 56th ASH Annual Meeting, San Francisco, 2014.
Sato A, Hirai H, Tamura A, Yokota A, Hayashi Y, Yao H, Yoshiioka S, Iwasa M, Miura Y, Maekawa T: C/EBPβ promotes initial expansion and exhaustion of hematopoietic stem cells in response to stresses. The 76th Annual Meeting of the Japanese Society of Hematology, 大阪, 2014.
Tamura A, Hirai H, Yokota A, Sato A, Yao H, Yoshioka S, Iwasa M, Miura Y, Ashihara E, Maekawa T: Critical roles of C/EBPβ for survival of Ly6C-Monocytes. The 76th Annual Meeting of the Japanese Society of Hematology, 大阪, 2014.
Iwasa M, Miura Y, Yao H, Yoshioka S, Fujishiro A, Tamura A, Sato A, Yokota A, Hirai H, Ando A, Ichinohe T, Maekawa T: Effect of irradiation on the characteristics of human bone marrow mesenchymal stromal/stem cells. The 76th Annual Meeting of the Japanese Society of Hematology , 大阪, 2014.
Yokota A, Hirai H, Maekawa M, Okuda K: C-terminal domain of ABL and ARG kinases defines their distinct leukemogenic activities in mice. The 76th Annual Meeting of the Japanese Society of Hematology, 大阪, 2014.
Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Yao H, Yoshioka S, Iwasa M, Miura Y, Maekawa T: Involvement of C/EBP β in IFN α-induced differentiation of BCR-ABL-expressing leukemic cells. The 76th Annual Meeting of the Japanese Society of Hematology, 大阪, 2014.
Yoshioka S, Miura Y, Yao H, Iwasa M, Fujishiro A, Higashi Y, Yokota A, Tamura A, Sato A, Hirai H, Ichinohe T, Takaori-Kondo A, Maekawa T: Isolation of mesenchymal stromal/stem cells from UCB ineligible for public UCB donation. The 76th Annual Meeting of the Japanese Society of Hematology, 大阪, 2014.
Hayashi Y, Hirai H, Kamio N, Yao H, Yoshioka S, Miura Y, Ashihara E, Fujiyama Y, Tenen DG and Maekawa T: C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion. Leukemia. 27(3): 619-28, 2013. doi: 10.1038/leu.2012.258.
Hirai H, Kamio N, Huang G, Matsusue A, Ogino S, Kimura N, Satake S, Ashihara E, Imanishi J, Tenen DG, Maekawa T: Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding proteinβ. PLoS One. 8(1): e54862, 2013. doi: 10.1371/journal.pone.0054862.
Fujii W, Ashihara E, Hirai H, Nagahara H, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y. Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis. J Immunol, 191 (3): 1073-81, 2013. doi: 10.4049/jimmunol.1203535
Okuda K and Hirai H: Distinct transforming activity of ABL family tyrosine kinase oncogenes is induced by their C-terminal domain. Open Journal of Blood Diseases. 3(3A): 23-33, 2013. doi: 10.4236/ojbd.2013.33A005
Itatani Y, Kawada K, Fujishita T, Kakizaki F, Hirai H, Matsumoto T, Iwamoto M, Inamoto S, Hatano E, Hasegawa S, Maekawa T, Uemoto S, Sakai Y and Taketo MM: Loss of Smad4 in Colorectal Cancer Cells Promotes CCL15 Expression to Recruit CCR1+ Myeloid Cells and Facilitate Liver Metastasis. Gastroenterology, 145(5): 1064-1075, 2013. doi: 10.1053/j.gastro.2013.07.033.
Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T: Cytokine-STATs signalings upregulate endogenous C/EBPβ in BCR-ABL+ leukemic cells independently from BCR-ABL signaling. American Society of Hematology, 55th Annual Meeting, New Orleans, 2013.
Tamura A, Hirai H, Hayashi Y, Yokota A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T: Cell-intrinsic and -extrinsic involvement of C/EBPβ in the regulation of hematopoietic stem cells. American Society of Hematology, 55th Annual Meeting, New Orleans, 2013.
Ashihara E, Nakagawa Y, Yao H, Yokota A, Miura Y, Takata K, Kitamura Y, Hirai H, Maekawa T: Hypoxia-Adapted Myeloma Cells Possess Stem Cell Character. American Society of Hematology, 55th Annual Meeting, New Orleans, 2013.
Yoshioka S, Miura Y, Yao H, Iwasa M, Sato A, Tamura A, Yokota A, Hishita T, Ichinohe T, Hirai H, Maekawa T: C/EBPβ expressed by bone marrow mesenchymal stromal cells is indispensable for precursor B-cell lymphopoiesis. American Society of Hematology, 55th Annual Meeting, New Orleans, 2013.
Fujii W, Ashihara E, Hirai H, Nagahara H, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y: Myeloid-derived suppressor cells have regulatory roles in mouse collagen-induced arthritis. Annual European Congress of Rheumatology, Madrid, 2013.
Fujii W, Nagahara H, Kajitani N, Fujioka K, Murakami K, Nakamura K, Seno T, Yamamoto A, Ishino H, Kohno M, Kawahito Y: Protective roles of myeloid-derived suppressor cells in autoimmune arthritis murine models through inhibiting pro-inflammatory immune response of CD4+ T cells. The 57th Annual General Assemble and Scientific Meeting of the Japan Collage of Rheumatology, Kyoto, 2013.
Yao H, Miura Y, Yoshioka S, Iwasa M, Sato A, Tamura A, Yokota A, Ashihara E, Ichinohe T, Hirai H and Maekawa T: Direct Interaction with Bone Marrow Mesenchymal Stromal/Stem Cells Is Required for Hematopoietic Expansion by Parathyroid Hormone. American Society of Hematology, 55th Annual Meeting, New Orleans, 2013.
Yao H, Miura Y, Yoshioka S, Hayashi Y, Yokota A, Tamura A, Ichinohe T, Hirai H and Maekawa T. Parathyroid hormone enhances expansion through CDH11 in human bone marrow mesenchymal stromal/stem cells. AsiaCORD 2013, Kobe, 2013.
Yoshioka S, Miura Y, Yao H, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaori-Kondo A and Maekawa T. C/EBPβ in mesenchymal stromal/stem cells regulates early B cell lymphopoiesis. AsiaCORD 2013, Kobe, 2013.
Tamura A, Hirai H, Hayashi Y, Yokota A, Yao H, Yoshioka S, Sato A, Iwasa M, Ashihara E, Miura Y, Maekawa T: Involvement of C/EBPβ in the regulation of hematopoietic stem cells. The 75th Annual Meeting of the Japanese Society of Hematology, Sapporo, 2013.
Yao H, Miura Y, Yoshioka S, Iwasa M, Sato A, Hayashi Y, Tamura A, Yokota A, Ichinohe T, Tohyama K, Hirai H, Maekawa T: Proliferation and differentiation of hematopoietic cells by osteogenic-induced bone marrow MSCs. The 75th Annual Meeting of the Japanese Society of Hematology, Sapporo, 2013.
Fujii W, Ashihara E, Hirai H, Fujioka K, Seno T, Ishino H, Kawahito Y: Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis. Annual Meeting of the Japanese Society for Immunology, 千葉, 2013.
Satake S, Hirai H, Hayashi Y, Shime N, Tamura A, Yao H, Yoshioka S, Miura Y, Inaba T, Fujita N, Ashihara E, Imanishi J, Sawa T and Maekawa T: C/EBPβ is involved in the amplification of early granulocyte precursors during candidemia-induced ‘emergency’ granulopoiesis. J Immunol. 189(9): 4546-55, 2012. doi: 10.4049/jimmunol.1103007.
学会発表
Hayashi Y, Hirai H, Yao H, Yoshioka S, Tamura A, Miura Y, Ashihara E, Fujiyama Y, Tenen DG and Maekawa T: C/EBPβ Is Upregulated Through STAT5 and Accelerates Exhaustion of Leukemic Stem Cells During BCR-ABL-Mediated Myeloid Expansion. 54th Annual Meeting and Exposition, American Society of Hematology, Atlanta, 2012.
Tamura A, Hirai H, Hayashi Y, Yao H, Yoshioka S, Miura Y, Ashihara E and Maekawa T: C/EBPβ-Mediated Expansion of Hematopoietic Stem/Progenitors Precedes ‘Emergency’ Granulopoiesis Induced by Candidemia. 54th Annual Meeting and Exposition, American Society of Hematology, Atlanta, 2012.
Fujii W, Ashihara E, Hirai H, Nagahara H, Murakami K, Nakamura K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y: Myeloid-derived suppressor cells accumulated in spleens of mice with collagen-induced arthritis and inhibited immune response od CD4+ T cells. American College of Rheumatology 2012 Annual Scientific Meeting, Washington, 2012.
Yao H, Miura Y, Yoshioka S, Hayashi H, Tamura A, Hirai H and Maekawa T: Mesenchymal Stem Cells Skewed Their Phenotype Toward the Osteogenic Lineage Support the Hematopoietic Cell Differentiation. 54th Annual Meeting and Exposition, American Society of Hematology, Atlanta, 2012.
Yoshioka S, Miura Y, Yao H, Hayashi Y, Tamura A, Ichinohe T, Hirai H, Takaori-Kondo A and Maekawa T: Expression of C/EBPβ in Bone Marrow Mesenchymal Stem Cells Is Mandatory for Early-Stage B Cell Lymphopoiesis. 54th Annual Meeting and Exposition, American Society of Hematology, Atlanta, 2012.
Hayashi Y, Hirai H, Tamura A, Yao H, Yoshioka S, Miura Y, Ashihara E, Fujiyama Y and Maekawa T: Involvement of C/EBPβ in the pathogenesis of chronic phase chronic myeloid leukemia. 第74回日本血液学会学術集会, 京都、2012.
Yoshioka S, Miura Y, Yao H, Hayashi Y, Satake S, Hishita T, Hirai H, Takaori-Kondo A and Maekawa T: Defective mesenchymal stem cells contribute to impaired B cell lymphopoiesis in C/EBPβ knockout mice. 第74回日本血液学会学術集会, 京都、2012.
Yao H, Miura Y, Yoshioka S, Hayashi Y, Ashihara E, Hirai H and Maekawa T: Parathyroid hormone stimulates mesenchymal stem cells to enhance expansion of hematopoietic cells. 第74回日本血液学会学術集会, 京都、2012.
Yao H, Ashihara E, Strovel JW, Nakagawa Y, Kuroda J, Nagao R, Tanaka R, Yokota A, Takeuchi M, Hayashi Y, Shimazaki C, Taniwaki M, Strand K, Padia J, Hirai H, Kimura S, Maekawa T: AV-65, a novel Wnt/β-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model. Blood Cancer J. 1(11): e43, 2011.
Nagao R, Ashihara E, Kimura S, Strovel JW, Yao H, Takeuchi M, Tanaka R, Hayashi Y, Hirai H, Padia J, Strand K, Maekawa T: Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65 - a novel Wnt/β-catenin signaling inhibitor. Cancer Lett. 312(1): 91-100, 2011.
Tanaka R, Kimura S, Ashihara E, Yoshimura M, Takahashi N, Wakita H, Itoh K, Nishiwaki K, Suzuki K, Nagao R, Yao H, Hayashi Y, Satake S, Hirai H, Sawada KI, Ottmann OG, Melo JV, Maekawa T: Rapid automated detection of ABL kinase domain mutations in imatinib-resistant patients. Cancer Lett. 312(2): 229-34, 2011.
Katsuyama M, Hirai H, Iwata K, Ibi M, Matsuno K, Matsumoto M, Yabe-Nishimura C: Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene. FEBS J. 278(6):964-72, 2011.
Sakai K, Kawata E, Ashihara E, Nakagawa Y, Yamauchi A, Yao H, Nagao R, Tanaka R, Yokota A, Takeuchi M, Hirai H, Kimura S, Hirashima M, Yoshimura N, Maekawa T: Galectin-9 ameliorates acute GVH disease through the induction of T-cell apoptosis. Eur J Immunol. 41(1): 67-75, 2011.
学会発表
Hayashi Y, Hirai H, Yao H, Yoshioka S, Satake S, Kamio N, Miura Y, Ashihara E, Fujiyama Y, Tenen DG, Maekawa T: BCR/ABL-Mediated Myeloid Expansion Is Promoted by C/EBPβ, a Regulator of Emergency Granulopoiesis. 53rd ASH Annual Meeting and Exposition, San Diego, 2011.
Yao H, Miura Y, Yoshioka S, Hayashi Y, Hirai H, Maekawa T: Parathyroid Hormone Stimulates Human Mesenchymal Stem Cells to Enhance the Expansion of Hematopoietic Stem Cells. 53rd ASH Annual Meeting and Exposition, San Diego, 2011.
Hayashi Y, Hirai H, Kamio N, Yao H, Satake S, Nagao R, Miura Y, Ashihara E, Maekawa T: Involvement of C/EBPβ in BCR/ABL-dependent leukemogenesis. 第73回日本血液学会学術集会, 名古屋, 2011.
Yao H, Ashihara E, Nagao R, Hayashi Y, Miura Y, Hirai H, Maekawa T: AV-65 inhibited the growth of myeloma cells by enhancing β-TrCP-mediated β-catenin ubiquitination. 第73回日本血液学会学術集会, 名古屋, 2011.
Tanaka R, Squires MS, Kimura S, Yokota A, Nagao R, Yamauchi T, Takeuchi M, Yao H, Reule M, Smyth T, Lyons JF, Thompson NT, Ashihara E, Ottmann OG, Maekawa T: Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells. Blood, 116(12); 2089-95, 2010.
Kamio N, Hirai H, Ashihara E, Tenen DG, Maekawa T and Imanishi J: Use of bicistronic vectors in combination with flow cytometry to screen for effective small interfering RNA target sequences. Biochem Biophys Res Commun 393(3): 498-503, 2010.
Umenai T, Hirai H, Shime N, Nakaya T, Asahara T, Nomoto K, Kita M, Tanaka Y, Imanishi J. Eradication of the commensal intestinal microflora by oral antimicrobials interferes with the host response to lipopolysaccharide. Eur J Clin Microbiol Infect Dis. 29(6): 633-41, 2010.
Takeuchi M, Ashihara E, Yamazaki Y, Kimura S, Nakagawa Y, Tanaka R, Yao H, Nagao R, Hayashi Y, Hirai H, Maekawa T: Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells. Cancer Sci. 102(3): 591-6, 2010.
Takeuchi M, Kimura S, Kuroda J, Ashihara E, Kawatani M, Osada H, Umezawa K, Yasui E, Imoto M, Tsuruo T, Yokota A, Tanaka R, Nagao R, Nakahata T, Fujiyama Y, Maekawa T: Glyoxalase-I is a novel target against Bcr-Abl (+) leukemic cells acquiring stem-like characteristics in a hypoxic environment. Cell Death Differ, 17(7); 1211-20, 2010.
Yokota A, Kimura S, Tanaka R, Takeuchi M, Yao H, Sakai K, Nagao R, Kuroda J, Kamitsuji Y, Kawata E, Ashihara E, Maekawa T: Osteoclasts are involved in the maintenance of dormant leukemic cells. Leuk Res, 34(6); 793-799, 2010.
Fujita Y, Ihara M, Ushiki T, Hirai H, Kizaka-kondoh S, Hiraoka M, Ito H, and Takahashi R: Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow. Stroke. 41(12): 2938-43, 2010.
Ushiki T, Kizaka-Kondoh S, Ashihara E, Tanaka S, Masuko M, Hirai H, Kimura S, Aizawa Y, Maekawa T, Hiraoka M: Noninvasive tracking of donor cell homing by near-infrared fluorescence imaging shortly after bone marrow transplantation. PLoS One. 5(6): e11114, 2010.
Kawata E, Ashihara E, Nakagawa Y, Kiuchi T, Ogura M, Yao H, Sakai K, Tanaka R, Nagao R, Yokota A, Takeuchi M, Kimura S, Hirai H, Maekawa T: A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro. Cancer Lett. 294(2): 245-53, 2010.
Yokoi H, Yamada H, Tsubakimoto Y, Takata H, Kawahito H, Kishida S, Kato T, Matsui A, Hirai H, Ashihara E, Maekawa T, Iwai M, Horiuchi M, Ikeda K, Takahashi T, Okigaki M, Matsubara H: Bone Marrow AT1 Augments Neointima Formation by Promoting Mobilization of Smooth Muscle Progenitors via Platelet-Derived SDF-1alpha. Arterioscler Thromb Vasc Biol. 30(1): 60-7, 2010.
Ashihara E, Munaka T, Kimura K, Kanai M, Abe H, Hirai H, Shoji S, Maekawa T. Isopentenyl Pyrophosphate (IPP), a Metabolite produced in Myeloma Cells, Induces the Chemotaxis of γδT Cells. 52nd ASH Annual Meeting and Exposition, Orlando, 2010.
Satake S, Hirai H, Shime N, Nagao R, Tanaka R, Yao H, Hayashi Y, Ashihara E, Inaba T, Fujita N, Imanishi J, Maekawa T. Candidemia-Induced Emergency Granulopoiesis Consists of Successive Dual Waves Triggered by the Shift From C/EBPα to C/EBPβ Dependency. 52nd ASH Annual Meeting and Exposition, Orlando, 2010.
Hirai H, Kamio N, Matsusue A, Ogino S, Kimura N, Satake S, Tanaka R, Nagao R, Yao H, Hayashi Y, Takeuchi M, Ashihara E, Huang G, Tenen DG, Imanishi J, Maekawa T: Involvement of CREBs in the regulation of C/EBPβ during "emergency" granulopoiesis. 第72回日本血液学会学術集会, 横浜, 2010.
Kamio N, Hirai H, Satake S, Tanaka R, Nagao R, Yao H, Hayashi Y, Takeuchi M, Ashihara E, Maekawa T: A flow cytometry-based method for screening of effective small interfering RNA target sequences. 第16回日本遺伝子治療学会年次学術集会, 栃木, 2010.
Kawata T, Ashihara E, Hirai H, Maekawa T: A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro. 第16回日本遺伝子治療学会年次学術集会, 栃木, 2010.
Nagao R, Hirai H, Satake S, Yao H, Tanaka R, Hayashi Y, Ashihara E, Maekawa T: The developmental process of myeloid-derived suppressor cells in the bone marrow of tumor-bearing mice. Kyoto University Global COE "Center for Frontier Medicine" International Symposium/Retreat2010, Hyogo, 2010.