Hanada K, Saito Y, Takagi T, Go M, Nakano Y, Inagawa T, Hirai H, Fruttiger M, Itoh S, and Itoh F: Reduced lung metastasis in endothelial cell-specific TGF-β type II receptor-deficient mice with decreased CD44 expression. iScience, in press
2024年
原著論文
Masui H, Itatani Y, Hirai H, Kiyasu Y, Hanada K, Okamoto M, Hirata W, Nishikawa Y, Sugimoto N, Tamura T, Sakai Y, Obama K, Nakanishi Y and Kawada K: Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment. British Journal of Cancer, 131(1):63-76, 2024.
Vanickova K, Milosevic M, Ribeiro Bas I, Burocziova M, Yokota A, Danek P, Grusanovic S, Chiliński M, Plewczynski D, Rohlena J, Hirai H, Rohlenova K, Alberich-Jorda M: Hematopoietic stem cells undergo a lymphoid to myeloid switch in early stages of emergency granulopoiesis. EMBO J;42(23): e113527, 2023.
Ikeda N, Kubota H, Suzuki R, Morita M, Yoshimura A, Osada Y, Kishida K, Kitamura D, Iwata A, Yotsumoto S, Kurotaki D, Nishimura K, Nishiyama A, Tamura T, Kamatani T, Tsunoda T, Murakawa M, Asahina Y, Hayashi Y, Harada H, Harada Y, Yokota A, Hirai H, Seki T, Kuwahara M, Yamashita M, Shichino S, Tanaka M, Asano K: The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell Rep. 42(3):112165, 2023.
Yokota A, Sakabe Y, Akaishi K, Inose M, Kamio N, Okuda H, Nishiyama A, Tamura T, Hirai H: C/EBPβ is involved in the regulation of CD135+ novel monocyte subset in mice. (転写因子C/EBPβはCD135陽性新規単球分画の分化制御に関与する) The 85th Annual Meeting of the Japanese Society of Hematology（第85回日本血液学会学術総会）, 東京, 2023.
神藤響生, 横田明日美, 平位秀世: ミエロイドへの分化過程における遠位エンハンサーによるC/EBPβ発現制御機構の解明. The 85th Annual Meeting of the Japanese Society of Hematology（第85回日本血液学会学術総会）, 東京, 2023.【優秀ポスター賞】
丹羽香央里, 岩本彰太郎, 花木良, 天野敬史郎, 豊田秀実, 丸山和晃, 今中恭子, 桝屋正浩, 俵功, 平位秀世, 平山雅浩: The role of macrophages in acute graft-versus-host disease after murine bone marrow transplantation. 第45回日本造血・免疫細胞療法学会総会, 名古屋, 2023.
Kamio N, Yokota A, Tokuda Y, Ogasawara C, Nakano M, Nagao M, Tashiro K, Maekawa T, Onai N and Hirai H: A novel CD135+ subset of mouse monocytes with a distinct differentiation pathway and antigen-presenting properties. J Immunol,209 (3): 498-509, 2022. doi: 10.4049/jimmunol.2100024.
Sugimoto N, Kanda J, Nakamura S, Kitano T, Hishizawa M, Kondo T, Shimizu S, Shigemasa A, Hirai H, Arai Y, Minami M, Tada H, Momose D, Koh, KR, Nogawa M, Watanabe N, Okamoto S, Handa M, Sawaguchi A, Matsuyama N, Tanaka M, Hayashi T, Fuchizaki A, Tani Y, Takaori-Kondo A and Eto K: iPLAT1: The first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study. Blood, 140(22):2398-2402, 2022. doi: 10.1182/blood.2022017296
Kamachi K, Ureshino H, Watanabe T, Yoshida N, Yamamoto Y, Kurahashi Y, Fukuda-Kurahashi Y, Hayashi Y, Hirai H, Yamashita S, Ushijima T, Okada S, Kimura S. Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia. Cancer Letters, 526: 273-283, 2022. doi: 10.1016/j.canlet.2021.11.032
Masuda T, Maeda S, Shimada S, Sakuramoto N, Morita K, Koyama A, Suzuki K, Mitsuda Y, Matsuo H, Kubota H, Kato I, Tanaka K, Takita J, Hirata M, Karaoke T, Nakahata T, Adachi S, Hirai H, Mizuta S, Naka K, Imai Y, Kimura S, Sugiyama H, Kamikubo Y. RUNX1 transactivates BCR-ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia. Cancer Science, 113(2): 529-539, 2022. doi: 10.1111/cas.15239
Hanada K, Fukasawa K, Hinata H, Imai S, Takayama K, Hirai H, Ohfusa R, Hayashi Y, Itoh F: Combination therapy of anamorelin with a myostatin inhibitor is advantageous for cancer cachexia in a mouse model. Cancer Science, 113 (10): 3547-3557, 2022. doi: 10.1111/cas.15491
Kamachi K, Ureshino H, Watanabe T, Yoshida N, Yamamoto Y, Kurahashi Y, Fukuda-Kurahashi Y, Hayashi Y, Hirai H, Yamashita S, Ushijima T, Okada S, Kimura S: Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia. Cancer Letters, 526: 273-283, 2022. doi: 10.1016/j.canlet.2021.11.032
Masuda T, Maeda S, Shimada S, Sakuramoto N, Morita K, Koyama A, Suzuki K, Mitsuda Y, Matsuo H, Kubota H, Kato I, Tanaka K, Takita J, Hirata M, Karaoke T, Nakahata T, Adachi S, Hirai H, Mizuta S, Naka K, Imai Y, Kimura S, Sugiyama H, Kamikubo Y: RUNX1 transactivates BCR-ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia. Cancer Science, 113(2): 529-539, 2022. doi: 10.1111/cas.15239
H, Mizuta S, Naka K, Imai Y, Kimura S, Sugiyama H, Kamikubo Y: RUNX1 transactivates BCR-ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia. Cancer Science, 113(2): 529-539, 2022. doi: 10.1111/cas.15239
学会発表
Yokota A, Kamio N, Tokuda Y, Ogasawara C, Nakano M, Tashiro K, Onai N, Hirai H: A novel mouse monocyte subset with a distinct differentiation path and antigen-presenting properties. 第84回日本血液学会学術集会, 福岡, 2022.
Sakabe M, Iwasawa K, Yokota A, Verba M, Boscolo E, Lu R, Takabe T, Xin M: The Hippo pathway effectors YAP and TAZ enhance venous differentiation through regulation of COUP-TFII expression. Cincinnati Children’s Hospital Medical Center, Heart Institute Retreat (Cincinnati, Ohio) September 13, 2022.
2021年
原著論文
Tang Y, Xu Q, Hu L, Yan X, Feng X, Yokota A, Wang W, Zhang D, Krishnamurthy D, Ochayon DE, Wen L, Huo L, Zeng H, Luo Y, Huang F, Wunderlich M, Zhang J, Vivier E, Zhou J, Waggoner SN, Huang G: Tumor microenvironment-derived R-Spondins enhance anti-tumor immunity to suppress tumor growth and sensitize for immune checkpoint blockade therapy. Cancer Discov, 11(12); 3142-3157, 2021.
Fan T, Feng X, Yokota A, Liu W, Tang Y, Yan X, Xiao H, Wang Y, Deng Z, Zhao P, Wang M, Wang H, Ma R, Hu X, Huang G: Arsenic dispensing powder promotes erythropoiesis in myelodysplastic syndromes via downregulation of HIF1A and upregulation of GATA factors. Am J Chin Med, 49(2); 461-485, 2021.
Cho K, Ushiki T, Ishiguro H, Tamura S, Araki M, Suwabe T, Katagiri T, Ohashi R, AjiokaY, Shimizu I, Okuda S, Masuko M, Nakagawa Y, Hirai H, Alexander WS, Shimano H and Sone H: Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic Socs3 deficiency. iScience, 24(10):103117, 2021. doi: 10.1016/j.isci.2021.103117.
学会発表
Sugimoto N, Kanda J, Nakamura S, Kitano T, Hishizawa M, Kondo T, Shimizu S, Shigemasa A, Hirai H, Tada H, Minami M, Watanabe N, Nogawa M, Handa M, Tani Y, Takaori-Kondo A, Eto K: The First-in-Human Clinical Trial of iPSC-Derived Platelets (iPLAT1): Autologous Transfusion to an Aplastic Anemia Patient with Alloimmune Platelet Transfusion Refractoriness. 63RD ASH ANNUAL MEETING AND EXPOSITION, Atlanta, 2021.
2020年
原著論文
Sato A, Kamion N, Yokota A, Hayashi Y, Tamura A, Miura Y, Maekawa T and Hirai H: C/EBPβ isoforms sequentially regulate regenerating mouse hematopoietic stem/progenitor cells. Blood Advances, 4(14):3343-3356, 2020.
Kiyasu Y, Kawada K, Hirai H, Ogawa R, Hanada K, Masui H, Nishikawa G, Yamamoto T, Mizuno R, Itatani Y, Kai M, Taketo MM, Sakai Y: Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice. Cancer Letters, 487: 53-62, 2020.
総説
Yokota A, Huo L, Lan F, Wu J, Huang G. The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies: Mol Cells, 43(2); 145-152, 2020.